Detailed information about selected course/program
EU code
12.4 - Veterinary Medicine
Mobility
3 - PhD
Location
Free University of Berlin, Germany
Subject
Department of Veterinary Medicine
Course/Program
PhD Degree in Defining hidden traits of the pandemic multi-resistant pathogenic E. coli lineage Sequence type 131 (ST131) to unravel the mechanisms of its successful worldwide spread
Language
English
Language requirements
Participants should be fluent in both written and spoken English. Applicants from countries where English is not the language of instruction need to have obtained a score of at least 550 on the TOEFL test (or a score of at least 213 on a computer TOEFL test) or provide proof of an equivalent test or provide proof that part of their education was in English.
Academic requirements
M. Sc. Life Sciences
Max available positions
1
Information
The development of multi-resistant bacteria is a key concern in medicine as individual patients cannot longer be treated successfully (“post antibiotic era”). The Extended-ß-lactamase (ESBL) producing E. coli of Sequence type 131 (ST131) is of particular concern as it is a virulent extraintestinal pathogenic E. coli (ExPEC) that has spread pandemically. The reason for this success is unclear, but it is discussed that a combination of virulence, multi-resistance and a particular genomic backbone confers this potential due to the ability of a genetic link between biofilm production and resistance. Starting with a total of 71 ST131 strains from humans, the environment and several animal hosts from two continents (Europe and Asia) which will be extended by our current and future clinical studies we will perform WGS and phenotypical assays for bacterial fitness to challenge our hypothesis. Furthermore we will unravel the microevolution of this highly virulent pandemic ST131.
Homepage
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Duration
36 months between Jul 15 2014 and Jul 14 2017
Contact person
Torsten Semmler (torsten.semmler@fu-berlin.de)