Detailed information about selected course/program
EU code
13.1 - Biology
Mobility
3 - PhD
Location
Free University of Berlin, Germany
Subject
Department of Biology, Chemistry, and Pharmacy
Course/Program
PhD Degree in Study of the evolution and function of protein complexity
Language
English
Language requirements
Participants should be fluent in both written and spoken English. Applicants from countries where English is not the language of instruction need to have obtained a score of at least 550 on the TOEFL test (or a score of at least 213 on a computer TOEFL test) or provide proof of an equivalent test or provide proof that part of their education was in English.
Academic requirements
MSc degree in Biological Sciences, average grade 2.4 or better (German grading system)
Max available positions
1
Information
Along evolution organisms have gained increased cellular complexity. Since proteins are an important part of the cell’s machinery, the evolution of the cell’s functional complexity is reflected by the evolution of protein sequences. Therefore, we propose to study the evolution of cellular complexity by studying the properties of protein sequences from hundreds of organisms whose genomes are completely sequenced. Protein may gain complexity during evolution by gaining global length, domains, disordered linkers, regulatory sites, and specific compositionally biased regions. Our analysis should answer questions about the order in which these properties evolved. In addition, the functional importance of disordered regions and compositionally biased regions is unclear and this study will suggest multiple evolutionary scenarios under which evolutionary pressure favoured their emergence, thus answering important questions that relate to protein function, interactions, aggregation and disease.
Homepage
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Duration
36 months between Jul 15 2014 and Jul 14 2017
Contact person
Dr. Miguel Andrade (miguel.andrade@mdc-berlin.de)